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125 mcg twice daily. 1) 5) 1) 5) The initial sotalol dose was calculated based on a daily dose of 90 mg/m2 and reduced by an age-related factor as recommended by the FDA approved prescribing information. Half-Life Elimination. Dose titration every 3 days monitored or 7 days in chronic use. This number means that the PO dose is 5 times more than the IV dose to get the same amount of drug into the bloodstream. Calculate the total daily opioid dosage (long acting and break through) and convert to morphine equivalents (either IV or PO) using an equianalgesic dosing table. Calculate new dose using ratios: 180/30 X 7.5 = 45 mg oral Hydromorphone/24 hours. Amiodarone is widely prescribed, largely due to its efficacy in the management of both supraventricular and ventricular arrhythmias. the Dose Factors (DFs) that we need to convert disintegrations in. This updated dose conversion is based on recent literature which has shown that the bioavailability of levothyroxine is estimated to be around 79-81 percent. Amiodarone Mechanism : Amiodarone is a class three anti-arrhythmic drug. Digoxin loading oral: 500-750mcg 2 doses 6 hours apart (max 1500mcg in 24 hours) Maintenance dose. Atrial Fib 150 mg IV/IO in 50 ml D5W/NS over 10 minutes. Round dose to a 30 mg increment, divide this daily dose by 4 to give Q6H dosing 3. 3. When infusions exceed 2 hours, amiodarone can absorb into the plastic used for standard IV bags. an oscillometric method.c Amiodaroned was administered, 200 mg/dog, PO q12h for 3.5 weeks, and then 200 mg/dog PO q24h for 3.5 addi-tional weeks. 290.914.916.010. You're typically looking at 400–600 mg daily in divided doses for 2–4 weeks. The drip has been infusing for almost 24 hours and the patient had not yet converted. It works in two ways (1) prolongation of the myocardial cell-action potential duration and refractory period and (2) non-competitive alpha- and beta-adrenergic inhibition. Flush with 20 ml of D5W/NS. If you're unable to convert to PO before 24 hours, consider decreasing the IV dose to 0.25 mg/min. For amiodarone, more than 20% of orders were canceled, but none were directly converted to the oral route. If intravenous amiodarone is administered during pregnancy, the patient should be apprised of the potential hazard to the fetus. Click to see full answer. some source region to absorbed dose in a target region…”. IV Esmolol infusion is fairly well supported by evidence. Subsequently, the dose may be decreased to 200 mg daily. Where volume is the amount of fluid in the IV bag, time is total number of minutes the fluid is to infuse over, and the drop factor (or drip factor) is related to the size of the IV tubing you are using; the number of drops per mL delivered for a particular drip chamber. Stable VT: 150 mg IV over 10 min May repeat with 150 mg IVP if needed. 11. Indication : Refractory supraventricular tachycardia; Junctional ectopic tachycardia; Atrial fibrillation The objective of this study was to assess the impact of IV and PO amiodarone overlap on short-term tachyarrhythmia recurrence and adverse hemodynamic outcomes in the intensive care unit. Ketorolac (Toradol®) Oral. 200mg tds. Store at 20° to 25°C (68° to 77°F) Protect from light. IV. 15 mg/hr to 480 mg/day. PO amiodarone 25.7 mg/kg vs. IV amiodarone 3‐5 mg/kg bolus then 10‐15 mg/kg over 24 h No difference in conversion to SR between PO and IV (64% vs. 68%, respectively; p=NS) 223 patients with symptomatic atrial fibrillation on digoxin PO amiodarone 600 mg in3 divided doses vs. IV amiodarone 5mg/kg over 2) Despite a reported duration of 5-8 hours, the peak/effective duration for IV is 30-60 minutes at best. For intravenous infusion ( Lanoxin ®), give intermittently in Glucose 5% or Sodium chloride 0.9%; dilute to a concentration of not more than … Calculate the flow rate to be set. IV fluids help if patient is dehydrated which can cause AFib. if 5 mg/325 mg, enter "5"). Calculate total daily oral dose 2. ... Amiodarone. Monitor BUN and serum creatinine q2days (qd if unstable). (anephric: 4-6 days). In practice, steroids may have to be administered alternatively or substituted for oral and IV administration. A client is receiving an IV solution of sodium chloride 0.9% (Normal Saline) 250 ml with amiodarone (Cordarone) 1 gram at 17 ml/hour. IV regimen: Bolus 0.15 mg/kg IV over 10 minutes, then 3-5 mg IV Q6hr. To prepare Amiodarone for an IV infusion, mix with D5W and give through an in-line filter. Oral Amiodarone • Amiodarone has a very long half life so requires a loading regime of 200mg tds for one week, bd for 2nd week then 200mg od • When a change in dose is part of a standard initiation regime, further details on the chart can ensure the change is automatically implemented and prevents missing the review date. IV. Maintenance = (Cl) (Cp) (t) Dose (F) Cp = (F) (dose/ t) Cl Cl equations for digoxin Reduce dose 50% for cross-tolerance: 45 x 0.5 = 22 mg/24 hours = 4 mg q4h. Steps to covert from diltiazem IV to PO 1. Oral maintenance dose. The patient was in Afib and the MD ordered a bolus of Ami followed by a continious drip. Calculate the Cp if a 70 yo, 70 kg man with a serum creatinine of 3.0 is given a 1 mg IV loading dose of digoxin. is a mathematical representation of the human body used to calculate. Amiodarone was discontinued and IV sotalol was initiated at 42 mg/m2/day, divided to 3 doses, and administered every 8 h, which completely suppressed the arrhythmia. Steroid Conversion Calculator. IV infusion IV Infusion IV Infusion (OB) Only REGULAR insulin may be administered by the IV route. 3. • After completion of a risk/benefit analysis, the QAS authorises the administration of sodium chloride 0.9% (flush or running IV line) following amiodarone administration in cardiac arrest, despite manufacturer’s recommendations. 5. EKG. DOSAGE. Posology. 100 unit / 100 ml (1 unit/ml). RxAdvanced: Guide to Cannabis training for pharmacists that offers 16 hours of ACPE-accredited training based on the latest, science-based cannabis research. Determine the new opioid analgesic to convert to and using equianalgesic dosing data (taking into consideration the limitations) convert to new opioid dose. Follow with a slow infusion of 360 mg over the next 6 hours (1 mg/min). Drugs; Diseases; Interaction Check; Pill ID; ... Dosing Calculator; Peds Dosing . However, patients in the metoral group (M) were given a dose of 1–3 mg/kg/h for 24 h. For each group, antiarrhythmia medicines were prescribed for 24 h. In adult patients, amiodarone can be given for VT/VF cardiac arrest via intravenous (IV)/intraosseous (IO) infusion as a 300 mg rapid bolus followed by an additional bolus of 150 mg IV/IO if VT or VF persists. Lidocaine. A dose of one 200-mg tablet (20 mg/kg q24h) was given to 6 dogs IV: 150 mg IV over 10 minutes. The physician orders amiodarone IV drip at 0.5 mg/min for ventricular dysrhythmias. received, X. N-desethylamiodarone (active metabolite): Prolonged in severe left ventricular dysfunction. The medication is supplied in 1 g/250 mL of D 5 W. Calculate the flow … VF and pulseless VT: 300 mg IV/IO push. How many mg/minute of amiodarone is infusing? (Enter numeric value only. View Critical Care Intravenous Flow Rates Quiz.docx from MATH 335 at El Dorado High School. Patients in the amiodarone group were given a STAT dose of 300 mg of amiodarone (A) followed by a dose of 1–3 mg/kg for every 6 h and 0.5 mg/kg 18 h later. 4. If the patient is taking 0.5 mg IV then the PO dose would be 0.5 mg multiplied by 5, which is 2.5 mg. Drug Usual IV Dose* Approximate PO Dose* PO to IV Considerations/Comments Reference digoxin 0.1 -0.4 mg IV Q 24 H 0.125 -0.5 mg PO Q 24 H Oral bioavailability about 80% for tablets and liquid 1,2 dimenhyDRINATE 25-50 mg IV 25-50 mg PO Conversion of … Note: This is for converting oral opioids only, and should not be used for IV to oral conversions. Only $199. Note: Half-life is shortened in children vs adults. Early switch over from IV to oral therapy has the following major advantages: Reduced risk of cannula-related infections: For the administration of IV medications, one is required to insert a cannula, which remains in place for some days and eventually can result in secondary infections caused by bacteria and fungi. (25033747, 10942741) Loading dose is 0.3-0.5 mg/kg IV (~30 mg). Dose: 150 mg IV x1 over 10min, then 1 mg/min IV x6h, then 0.5 mg/min IV x18h [PO route] Dose: 400 mg PO qd; Start: load 800-1600 mg PO qd x1-3wk until response, then 400-600 mg PO qd x4wk; Info: divide loading doses >1000 mg/day bid-tid w/ meals; divide maint. Loading dose. Alternative regimen of amiodarone: 600 mg/day for 7 days prior to surgery, followed by 200 mg/day until hospital discharge, has also been shown to decrease the risk of postoperative atrial fibrillation. This calculator is not appropriate for the following patient populations: Significant drug interactions (eg, amiodarone, quinidine, verapamil, or macrolide antibiotics) End-stage renal disease on hemodialysis; Acute renal failure or unstable renal function; The following bioavailabilities (F) are used for calculation: Tablet = 0.75; Intravenous = 1 Can be used to convert between corticosteroid medication dosages for oral and IV administration. Start at 400 mg PO BID, until the patient has received a total of 10 grams cumulative dose (both IV and PO). All microdrip tubing delivers 60 gtt/mL and is used to deliver a small or very precise amount of fluid. Upon Intravenous amiodarone has interesting and complex pharmacokinetics. Digoxin Second line rate control agent, primarily because it tends to exert its rate controlling effect at rest, Warfarin As you can imagine, many of the patients cant take PO, pick your variety of reasons: SBO, Postoperative Ileus, Sigmoid Cancer, blah blah blah. Intravenous to Oral Conversion for Antimicrobials 1-20-6-1-010 Author(s): Antimicrobial Stewardship Program Coordinator Page 6 of 6 Issuing Authority: Vice President Medicine and Clinical Programs; Regional Director, Pharmacy Services QT interval from excess amiodarone administration, magnesium sulphate administration is to be considered. Dogs were given amiodarone at 8:00 AM and 8:00 PM daily for the loading dose and at 8:00 AM daily for the maintenance. 1. Thus, although a starting dose adequate to suppress life-threatening arrhythmias is needed, close monitoring with adjustment of dose as needed is essential.The recommended starting dose of Cordarone I.V. Amiodarone is an iodinated benzofuran derivative that was synthesized and tested as an antianginal agent in the 1960s but was later discovered to have antiarrhythmic properties. Flush post dose. 1) IV metoprolol has immediate action, PO has slow and graded release over hours. 125 mcg once a day. For example, patients are frequently prescribed intravenous glucose 5%. Serious side effects may include lung or liver problems. Description. Cardizem 5-20mg iv bolus [or Metoprolol 5mg IV], a repeat dose may be needed in 15min and if not converted to sinus–>Cardizem iv drip starting with 5mg/hr [or Amiodarone bolus f/b drip if BP is low.] Pharmacist –initiated IV to PO conversion program of antimicrobials. followed by 20 ml saline flush Amiodarone 50 mg/ml vial Pulseless VT or VF: 300 mg IVP. Dose titration every 3 days monitored or 7 days in chronic use. From what I've been taught IV Amio has immediate effect, while PO Amio takes days/weeks to kick in. Amiodarone shows considerable interindividual variation in response. IV: 30 mg/kg over 15 min, followed in 45 min by a continuous infusion of 5.4 mg/kg per h for 23 h. Administration within 8 h of injury is optimal. Try the most comprehensive online opioid calculator available! It exhibits all four of the classic Vaughan Williams mechanisms of action, namely sodium and potassium channel blockade, a mild antisympathetic action and some calcium channel blockade, but it is usually classified as a Class III antiarrhythmic drug (see Table 1).It prolongs the … Calculate the 24 hour current dose: 90 Q12 x 2 = 180 mg PO Morphine/24 hrs. • Also remove sticky note when IV to po is addressed. Drug Usual IV Dose* Approximate PO Dose* PO to IV Considerations/Comments Reference digoxin 0.1 -0.4 mg IV Q 24 H 0.125 -0.5 mg PO Q 24 H Oral bioavailability about 80% for tablets and liquid 1,2 dimenhyDRINATE 25-50 mg IV 25-50 mg PO Conversion of … INSTRUCTIONS. Critical Care Intravenous Flow Rates Example 1: The order is to infuse nitroglycerin at 5 mcg/min; 50 mg of Study Resources IV Infusion Concen- tration Usual Dosing and Administration Comments Amiodarone X (Cordarone®) exceeding c X Bolus in ode only No infusion X Bolus diluted to 1.5 -3 mg/mLin D5W Infusion 450 mg/ 250 mL in D5W BOLUS: PALS for pulseless VF/VT5 mg/kg (MAX 300 mg/dose) given over 5 10 minutes. Monitor apical pulse daily. No matter which strategy you follow with amiodarone, the goal is to transition to PO within 24 hours. 4. 250 mcg twice daily. Negative inotropy is an adverse feature of most antiarrhythmic drugs. With intravenous use: Avoid rapid intravenous administration (risk of hypertension and reduced coronary flow). The pharmacist leaving the sticky not will open and IV to po i-Vent, leave this i-Vent open until the medication is changed. The plasma half-life of amiodarone after single-dose administration has been reported to be in the range of 3.2 to 79.7 hours. Amiodarone: Single dose: 58 days (range: 15 to 142 days) Oral chronic therapy: Mean range: 40 to 55 days (range: 26 to 107 days) IV single dose: Mean range: 9 to 36 days. A percentage means ‘out of 100’, so a percentage concentration can be defined as the amount of drug in 100 parts of the product. [onset time < 20min] EP or general cardiology consult should be requested if long-term amiodarone use is contemplated. Detailed Amiodarone dosage information for adults. After IVP, Flush with 20 ml of D5W or NS. 15mg q6hr, even if equivalent, is hitting them with a whopping dose upfront. Prepare solution with 900 mg amiodarone in 500 mL D5W glass bottle. Give VERY RAPID IVP over 1-3 sec. How to load digoxin. 2. Also, this drug stays in your body for weeks to months, even after you are no longer taking it. Typical amiodarone dosages in the ACLS setting are provided in Table 1. Amiodarone HCl 30 mg IV J0282 Amitriptyline HCl up to 20 mg IM J1320 Amobarbital up to 125 mg IM, IV J0300 Amphocin, see Amphotericin B Amphotericin B 50 mg IV J0285 Amphotericin B, lipid complex 10 mg IV J0287-J0289 … In the text below the tool you can find out more about the substances that are available to be converted. 62.5mcg – 250mcg daily. 1)The physician orders amiodarone IV drip at 0.5 mg/min for ventricular dysrhythmias. 3. 125 mcg twice daily. HOW SUPPLIED -----Amiodarone Hydrochloride Injection, 50 mg/mL is supplied in: 3 mL (150 mg) 10 Single-dose vials per carton (NDC 60505-0722-0). You can discover more on this subject, check an example calculation and the half times of most known active substances below the form. To determine the dose conversion IV to PO, the ratio of PO to IV needs to be determined, this is 7.5 / 1.5 which is 5. 5. IV/IM: 1–2 mg/kg initial dose (must use acetate salt for IM route). Description. 3. If rounding is required, round to the nearest tenth.) Amiodarone may take 2 weeks or longer to have an effect in your body. Cumulative dose, X = (total IV dose * 2) - (days of treatment * 200); This is then used to determine the appropriate loading dose: -. Peak serum concentrations after 15-minute infusions in healthy volunteers range from 5 to 41 mg/L. The medication is supplied in 900 mg/500 mL of D 5 W. Calculate the flow rate in milliliters per hour.. 2) The physician orders a lidocaine IV drip to infuse at 3 mg/min for premature ventricular contractions. Loop diuretic PO --> IV conversions Furosemide 40 mg PO = Furosemide 20 mg IV = Torsemide 20 mg PO/IV = Bumetanide 1 mg PO/IV #Pharmacology #Cardiology #Loop #Diuretics #Equivalent #Dose #Conversion #Table #Furosemide #Torsemide #Bumex #Lasix #Bumetanide ** GrepMed Recommended Text: Clinical Pharmacology Made … Amiodarone increases PO digoxin serum concentrations by ~70% and IV digoxin by ~17%; measure digoxin levels before initiating amiodarone and reduce PO digoxin dose by 30-50%; decrease IV digoxin dose by 15-30% amiodarone will increase the level or effect of digoxin by basic (cationic) drug competition for renal tubular clearance. The dosing schedule of amiodarone, with intravenous loading protocols, may mean that the automated intravenous to oral conversion prompt does not provide physicians with the dose recommendations they need for this drug. received via the IV route, as follows: -. Onset/peak: IV: 5-30min/ 1-4hrs Oral: 1-2hrs/ 2-8 hrs. Adjust to the lowest possible dose to limit side effects. The following pharmacist will check on these open i-Vents and close then when appropriate. 26 - 107 days. Chronic use of amiodarone causes a host of side effects. IV/PO: 4-8 hrs initially; increases to 22-48 hrs with repeated doses. New! Oct 27, 2007. Cumulative dose. Description. 3 Based on this data, the ATA Guidelines and Lexicomp recommend administering an IV dose that is 75 percent of the oral dose when converting from a parenteral to enteral route. The objective of this study was to assess the impact of IV and PO amiodarone overlap on short-term tachyarrhythmia recurrence and adverse hemodynamic outcomes in the intensive care unit. Asymptomatic blue-grey discolouration of exposed areas can also occur. Patient had also received 3 doses of PO Amio in addition to the drip in the 24 hours. Includes dosages for Arrhythmias; plus renal, liver and dialysis adjustments. 12 mg IV x1 dose. Suggested Pediatric Drug Dosages 07/05/2005 Zwi Jacob, MD Download 2 page pdf version for printing The dosages and drugs are intended as general guidelines ONLY. Percocet = acetaminophen + oxyCODONE), enter only the dose of the opioid component (e.g. Step 6. The patient was also started on PO amiodorone 400mg BID. IV/PO: 4-8 hrs initially; increases to 22-48 hrs with repeated doses. At 2–3 hours after each subsequent dose of Tikosyn, determine the QTc or QT (if heart rate is less than 60 beats per minute) (for in-hospital doses 2–5). Automatic IV to PO Conversion Protocol Purpose: To allow for the conversion of intravenous medications to oral equivalents when medically appropriate in an effort to reduce line-associated risk, reduce nosocomial-acquired infection risk, improve patient satisfaction, promotes earlier and easier ambulation, and reduce May repeat every 10 minutes PRN. Guardrail Drug Requires documentation of two (2) RN’s for double-checking. PO. 2. This has to do with the very high volume of distribution (part of why you give the 150mg load). Eventually transition to another agent. Calculate the number of units required to deliver the initial bolus dose. 154/ 2.2 = 70 kg 70 x 80 = 5,600. (10942741, 25745472, 32345562) Oral regimen: Propranolol 40 mg PO q6hrs has been proven superior to metoprolol (50 mg q6hr). Faebinder said: Our floor policy (as in the floor where I admit 90% of my patients) frigging wont give lopressor IV even if the person was on lopressor PO prior to admission. Restated: Duration of IV infusion < 1 week: 800-1600mg/day po initially x 1-2 weeks or complete current week; 1-3 weeks: 600-800mg/day po initially - total therapy ~ 1 month counting IV infusion ; >3 weeks: 400mg po qd initially. However, after withdrawal of long term amiodarone treatment the half-life is as long as 100 days. VT with pulse (stable) and SVT: 150 mg IV/IO in 50 ml D5W/NS over 10 minutes. The actual drugs and their doses should be administered only following discussion with the attending. Then you'd transition to a maintenance dose of 100 - 200 mg daily. Common IV to PO Drug Conversions 1) Metoprolol 1:2.5 2) Diltiazem Oral Dose (mg/day) = [ rate (mg/hr) x 3 + 3 ] x 10 3) Digoxin 0.75:1 4) Levothyroxine 0.75:1 5) Aminophylline to Theophylline 1:0.8 6) Ciprofloxacin 1:1.25 #IVtoPO #Drug #Conversion #Pharmacology #Common #Intravenous #Oral. If the patient achieves ROSC, a continuous infusion is started at 1 mg/min for 6 hours, followed by 0.5 mg/min. Peak levels after 150 mg of supplemental infusions in patients with VT/VF range between 7 and 26 mg/L. IV amiodarone must be administered via a central line. Infusion Pump Required. The medication is supplied in 15 mg/mL. Articles describing intravenous to oral conversion protocols for any therapeutic category were identified in an English-language MEDLINE search (1990-April 2010) using a … What is the rate of the infusion in mL/h? This medicine half life calculator estimates the action of any medicine and the way concentration decreases in percentage in plasma according to half life and dosage. 0.22 micron filter preferred . Alternatively, it is NOT necessary to dilute amiodarone for IV push administration and a filter is not necessary. IV Push for Hyperkalemia. Infuse 150 mg over 10 minutes (15 mg/min). Digoxin loading dose IV: 500mcg; followed by 250mcg 6 hours later and a further 250mcg 6 hours after that. Use the equianalgesic ratio: 30 mg PO Morphine = 7.5 mg PO Hydromorphone. Amiodarone IV bolus at 150mg over 1 minute, then 1mg/min for 6hours and then 0.5mg/min for 18hours. IV loading should only be performed when a rapid response is required. For combination drugs (e.g. Next. Half-life: 38-48 hrs. Amiodarone Intravenous should only be used in a special care unit under continuous monitoring (ECG and blood pressure). IV infusion is preferred to bolus due to the haemodynamic effects sometimes associated with rapid injection (see section 4.8). 1 yr. ago. amiodarone pediatric dosing. Medline ® Abstract for Reference {{configCtrl2.info.canonicalUrl}} of 'Amiodarone: Clinical uses' I've seen an IV Amio bolus drop pressures, but that's typically when it's given over 15 minutes. Loop diuretic PO --> IV conversions Furosemide 40 mg PO = Furosemide 20 mg IV = Torsemide 20 mg PO/IV = Bumetanide 1 mg PO/IV #Pharmacology #Cardiology #Loop #Diuretics #Equivalent #Dose #Conversion #Table #Furosemide #Torsemide #Bumex #Lasix #Bumetanide ** GrepMed Recommended Text: Clinical Pharmacology Made … This will change the medication concentration. Although amiodarone exerts its antiarrhythmic effect by an interplay of different actions on cardiac cells, it has been regarded to be the prototype class III drug due to its prolongation of action potential duration. For oral dosage form (tablets): For ventricular arrhythmias: Adults—At first, 800 to 1600 milligrams (mg) per day taken in divided doses. <2400mg. Equivalents are based on 30 mg morphine PO = 10 mg morphine IV = 100 mcg fentanyl IV = 30 mg HYDROcodone PO = 1.5 mg HYDROmorphone IV = 7.5 mg HYDROmorphone PO = 20 mg OXYcodone PO = 1 mg OXYmorphone IV = 10 mg OXYmorphone PO Looking for a more detailed calculator? No further down titration of Tikosyn based on QTc or QT is recommended. Loading dose: 800–1,600 mg/day PO in divided doses, for 1–3 wk; reduce dose to 600–800 mg/day in divided doses for 1 mo; if rhythm is stable, reduce dose to 400 mg/day in one to two divided doses for maintenance dose. Methods. including oral and intravenous regimens: -Oral: Starting in postop recovery, 400 mg twice daily for up to 7 days. 2, 10 In patients who require long-term treatment, intravenous dosing should be switched to oral dosing. The physician orders Zantac elixir 150 mg po twice a day for heartburn. 12. Follow up with an infusion of 1 mg/min IV x 6 hours, then 0.5 mg/min IV x 18 hours. Oral loading dose. DOSAGE AND ADMINISTRATION. VT with pulse unstable: 1st dose 150mg IVP/IOP under 2 minutes - 2nd dose 150mg IV/IO in 50ml D5W/NS over 10 min. A patient started on oral (PO) amiodarone approximately 1 week ago (400 mg/day). Therefore, serious side effects may occur weeks to months after taking amiodarone. Time to steady state: 5-7 days (average) ESRD: 15-20 days. What is the simpliest method to calculate this into ml/hr. Give first PO dose 1 hour prior to ... Amiodarone PO dosing in hospital After converts to NSR or after 24 hrs, 400mg PO BID up to 10g load (includes IV), then 200mg daily. Also, the number of doses you take each day, the time allowed between doses, and the length of time you take the medicine depend on the medical problem for which you are using the medicine. RADAR Phantoms Calculator INPUT Values include: Phantom “…Adult Male & Male; 15, 10, 5, 1 Year Old; Newborn; etc…”. For continuous infusions, conc. • Then i-Vents acuity will now have a 10 to signify there is a open i-Vent. Dexamethasone 0.6 mg/kg IV/IO/ IM/PO Maximum daily dose 16 mg Methylprednisolone sodium succinate 1–2 mg/kg IV/IO/IM Maximum single dose 60 mg ... Do not give with amiodarone Sodium Bicarbonate 1 mEq/kg IV/IO Give as a slow bolus Use 4.2% concentration in infants less than 1 month of age Seizures Drug Dose Comment Prepare solution with 150 mg amiodarone in 100-mL D5W bag. #23. Mr Smith is to receive 800 mL of an antibiotic via an IV infusion over 15 hours. IV: 0.05–0.10 mg/kg given over 2–3 min (maximum single dose: 5 mg). Amiodarone should only be used when facilities exist for cardiac monitoring, defibrillation, and cardiac pacing. Continuous infusion: Bolus 150 mg over 10 min, then start drip. Amiodarone [SVT with pulses] 150mg Rapid infusion over 10 minutes 15mg/minute, may repeat q10 minutes as needed Stable in D5W, NS Incompatible with heparin Maximum cumulative dose 2.2g over 24 hours Ativan (lorazepam) 0.1mg/kg Max dose 4mg Dilute 1:1 with NS Max rate 2mg/minute Stable in D5W, LR, NS Monitor IV site avoid extravasation The initial infusion rate is not greater than 30 mg/min. Intravenous administration Extravasation of amiodarone can cause significant tissue damage including necrosis. Calculate the flow rate if 1.2 L is to be infused over 24 hours. doses bid w/ meals if GI intolerance Amiodarone is an antiarrhythmic drug with structural similarities to thyroxine. This means that each 100ml of water in … This should be administered as a dilute solution in 250ml 5% w/v dextrose. Calculate the oral loading dose for a 70 yo, 70 kg adult male with a serum creatinine of 3.0, if the desired Cp is 1.0 ng/ml. is about 1000 mg over the first 24 hours of … The total daily dose should be divided q6h. The standard recommended dose is 5mg/kg bodyweight given by intravenous infusion over a period of 20 minutes to 2 hours. Note: Pharmacy sent the bolus in a separate 100 ml bag and the continuous drip in a 500 ml bag. Amiodarone increases PO digoxin serum concentrations by ~70% and IV digoxin by ~17%; measure digoxin levels before initiating amiodarone and reduce PO digoxin dose by 30-50%; decrease IV digoxin dose by 15-30% amiodarone will increase the level or effect of digoxin by basic (cationic) drug competition for renal tubular clearance.